Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
Identifieur interne : 006687 ( Main/Exploration ); précédent : 006686; suivant : 006688Do enkephalins in basal ganglia mediate a physiological motor rest mechanism?
Auteurs : M. L. De Ceballos [Royaume-Uni] ; M. Baker [Royaume-Uni] ; S. Rose [Royaume-Uni] ; P. Jenner [Royaume-Uni] ; Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1986.
English descriptors
- KwdEn :
- Animals, Basal Ganglia (analysis), Basal ganglia, Biogenic Monoamines (analysis), Burns (physiopathology), Dopamine (metabolism), Enkephalin, Leucine (analysis), Enkephalin, Methionine (analysis), Enkephalins, Enkephalins (analysis), Locomotion, Male, Pain (physiopathology), Rats, Rats, Inbred Strains, Rest, Rest mechanisms, Sensory Thresholds (physiology), Thermal injury, Time Factors.
- MESH :
- chemical , analysis : Biogenic Monoamines, Enkephalin, Leucine, Enkephalin, Methionine, Enkephalins.
- analysis : Basal Ganglia.
- chemical , metabolism : Dopamine.
- physiology : Sensory Thresholds.
- physiopathology : Burns, Pain.
- Animals, Locomotion, Male, Rats, Rats, Inbred Strains, Rest, Time Factors.
Abstract
Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.
Url:
DOI: 10.1002/mds.870010402
Affiliations:
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L." last="De Ceballos">M. L. De Ceballos</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rose, S" sort="Rose, S" uniqKey="Rose S" first="S." last="Rose">S. Rose</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jenner, P" sort="Jenner, P" uniqKey="Jenner P" first="P." last="Jenner">P. Jenner</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1986">1986</date><biblScope unit="vol">1</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5B639AD929ED9CFA3FC59C428CB09C55E88AEBC0</idno><idno type="DOI">10.1002/mds.870010402</idno><idno type="ArticleID">MDS870010402</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Basal Ganglia (analysis)</term><term>Basal ganglia</term><term>Biogenic Monoamines (analysis)</term><term>Burns (physiopathology)</term><term>Dopamine (metabolism)</term><term>Enkephalin, Leucine (analysis)</term><term>Enkephalin, Methionine (analysis)</term><term>Enkephalins</term><term>Enkephalins (analysis)</term><term>Locomotion</term><term>Male</term><term>Pain (physiopathology)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Rest</term><term>Rest mechanisms</term><term>Sensory Thresholds (physiology)</term><term>Thermal injury</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biogenic Monoamines</term><term>Enkephalin, Leucine</term><term>Enkephalin, Methionine</term><term>Enkephalins</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Basal Ganglia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sensory Thresholds</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Burns</term><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Locomotion</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Rest</term><term>Time Factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thermal injury (30‐s immersion in water at 62°C) of one hind limb of rats caused a gradual withdrawal of the limb from use, such that after 1 week 50% of the animals walked on three legs. At 24 h following thermal lesion and at a time when the lesioned paw was still used for walking there was a reduction in met‐and leu‐enkephalin content in the periaqueductal grey (PAG) and bilateral reduction in leu‐enkephalin content of the globus pallidus, but no change in enkephalin levels in caudate‐putamen. One week following the lesion, animals exhibiting complete withdrawal of the injured limb, showed bilateral reduction of met‐ and leu‐enkephalin content of PAG. Both met‐ and leu‐enkephalin were bilaterally reduced in globus pallidus as was the met‐enkephalin content in caudate‐putamen. In each case the change was more marked in basal ganglia areas contralateral to the lesion. In animals lesioned 1 week previously and which did not use the injured limb, there was no change in the monoamine (or metabolite) content of caudate‐putamen or in the spontaneous or potassium‐evoked release of 3H‐dopamine from striatal slices. Thermal injury did not cause any general change in pain sensitivity and the time of change in pain threshold in the injured limb did not parallel the withdrawal of the affected limb from walking. The results suggest that after a thermal limb lesion, delayed changes in basal ganglia enkephalin content may be important in withdrawing the injured limb from the normal pattern of locomotion. Basal ganglia enkephalins may be involved in a physiological rest mechanism, which allows healing of the affected part.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="De Ceballos, M L" sort="De Ceballos, M L" uniqKey="De Ceballos M" first="M. L." last="De Ceballos">M. L. De Ceballos</name></region><name sortKey="Baker, M" sort="Baker, M" uniqKey="Baker M" first="M." last="Baker">M. Baker</name><name sortKey="Jenner, P" sort="Jenner, P" uniqKey="Jenner P" first="P." last="Jenner">P. Jenner</name><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><name sortKey="Rose, S" sort="Rose, S" uniqKey="Rose S" first="S." last="Rose">S. Rose</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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